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What is DME?

Diabetic macular edema (DME) is a complication associated with diabetes

Understanding how DME affects your eye, and your vision, can help shape your treatment choices.

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DME AND YOUR EYE

DME AND YOUR VISION

DME AND YOUR EYE

How DME affects your eye

VEGF and Ang-2 are proteins that help keep blood vessels in your eyes healthy. When their levels are too high, it can lead to eye problems such as DME.

Healthy eye

In a healthy eye, VEGF and Ang-2 keep blood vessels stable and working properly, supporting clear vision.

Eye with DME

In DME, VEGF and Ang-2* cause blood vessels to grow abnormally, swell, and leak fluid. This can lead to blurry vision or vision loss.

*Levels of Ang-2 proteins are increased in some people with DME.
Ang-2=angiopoietin-2; VEGF=vascular endothelial growth factor.

DME AND YOUR VISION

How DME affects your vision

Slide to see how DME impacts the way you see your world in more ways than one.

Central vision Lines Color Light

Vision unaffected by Central Vision issue

Vision affected by Central Vision issue

Blurry or blind spots can appear in the center of your vision

Vision unaffected by lines issue

Vision affected by lines issue

Straight lines that appear wavy

Vision unaffected by Color issue

Vision affected by Color issue

Colors that appear less vibrant

Vision unaffected by light issue

Vision affected by light issue

Trouble seeing in low light

VABYSMO^® is the only FDA-approved treatment thought to block 2 causes of DME^†

VABYSMO^® is the only FDA-approved treatment thought to block 2 causes of DME^†

^†VABYSMO is thought to block the VEGF and Ang-2 proteins. The benefit of blocking Ang-2 has yet to be established.

We want to support your journey

Explore our brochure for helpful information about VABYSMO^® and what to expect during treatment.

NEXT: What is VABYSMO?

NEXT: What is VABYSMO?

What is VABYSMO?

VABYSMO (faricimab-svoa) is a prescription medicine given by injection into the eye used to treat adults with neovascular (wet) age‑related macular degeneration (AMD), diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO).

Do not receive VABYSMO if you:

Have an infection in or around your eye.
Have active swelling around your eye that may include pain and redness.
Are allergic to VABYSMO or any of the ingredients in VABYSMO.

What is the most important information I should know about VABYSMO?

Injections like the one for VABYSMO can cause an eye infection (endophthalmitis), separation of layers of the retina (retinal detachment), or inflammation in the eye that can lead to vision loss. Call your healthcare provider right away if your eye becomes red, sensitive to light, or you have a change or loss of vision.
VABYSMO may cause a temporary increase in pressure in the eye (intraocular pressure), which occurs within 60 minutes after receiving the eye injection.
Although not common, VABYSMO patients have had serious, sometimes fatal, problems related to blood clots, such as heart attacks or strokes (thromboembolic events). In clinical studies for wet AMD during the first year, 7 out of 664 patients treated with VABYSMO reported such an event. In clinical studies for DME from baseline to week 100, 64 out of 1,262 patients treated with VABYSMO reported such an event. In clinical studies for RVO during 6 months, 7 out of 641 patients treated with VABYSMO reported such an event.
Severe inflammation of vessels in the retina has happened for patients treated with VABYSMO. Call your healthcare provider immediately if you experience a change in vision.

Before receiving VABYSMO, tell your healthcare provider about all of your medical conditions, including if you:

Are pregnant or plan to become pregnant. Based on how VABYSMO interacts with your body, there may be a potential risk to your unborn baby. You should use birth control before your first injection, during your treatment with VABYSMO, and for 3 months after your last dose of VABYSMO.
Are breastfeeding or plan to breastfeed. It is not known if VABYSMO passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive VABYSMO.
Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about all the medicines you take.

What should I avoid while receiving VABYSMO?

Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects with VABYSMO?

The most common side effects with VABYSMO were cataract and blood on the white of the eye (conjunctival hemorrhage).
These are not all the possible side effects of VABYSMO.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to Genentech at 1-888-835-2555.

Please see the VABYSMO full Prescribing Information for additional Important Safety Information.