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For US Healthcare Professionals

Diabetic Macular Edema (DME)

Learn about wet age-related macular degeneration (AMD)

Woman at doctor appointment

Learning what causes wet AMD can help you identify how to best treat it

Wet age-related macular degeneration (AMD) is a leading cause of vision loss in adults aged 60 and over.

Did you know?

  • Each person with wet AMD experiences their condition differently
  • People with wet AMD in one eye may be more likely to develop wet AMD in their other eye
Central Vision Lines Color Light

Slide to see how wet AMD can impact the way you see your world

Normal vision
Blurry or blind spots can appear in the center of your vision

Blurry or blind spots can appear in the center of your vision

Slide to see how wet AMD can impact the way you see your world

Normal vision
Straight lines appear wavy

Straight lines that appear wavy

Slide to see how wet AMD can impact the way you see your world

Normal vision
Colors appear less vibrant

Colors that appear less vibrant

Slide to see how wet AMD can impact the way you see your world

Normal vision
Trouble seeing in low lighting

Trouble seeing in low light

WHAT HAPPENS IN THE EYE WITH WET AMD

wet AMD within the eye (graphic)
Letter A

Blood vessels grow abnormally in the eye.

Letter B

The abnormal blood vessels leak fluid into the macula—the part of the eye that controls sharp, straight-ahead vision.

Letter C

The macula swells, leading to blurred vision and vision loss.

There are multiple proteins in the eye that cause swelling.

VEGF and Ang-2* are 2 proteins in the eye that cause blood vessels to grow abnormally, swell, and leak fluid. This can lead to retinal damage and various symptoms of vision loss for people with wet AMD.

*Levels of Ang-2 proteins are increased in some people with wet AMD.

Ang-2=angiopoietin-2; VEGF=vascular endothelial growth factor.

There are multiple proteins in the eye that cause swelling.

VEGF and Ang-2* are 2 proteins in the eye that cause blood vessels to grow abnormally, swell, and leak fluid. This can lead to retinal damage and various symptoms of vision loss for people with wet AMD.

*Levels of Ang-2 proteins are increased in some people with wet AMD.

Ang-2=angiopoietin-2; VEGF=vascular endothelial growth factor.

VABYSMO® is the first and only FDA-approved treatment designed to block 2 causes of wet AMD (VEGF and Ang-2†)

LEARN HOW VABYSMO WORKS DIFFERENTLY

†The benefit of blocking Ang-2 has not been fully determined.

VABYSMO® is the first and only FDA-approved treatment designed to block 2 causes of wet AMD (VEGF and Ang-2†)

LEARN HOW VABYSMO WORKS DIFFERENTLY

†The benefit of blocking Ang-2 has not been fully determined.

IMPORTANT SAFETY INFORMATION

What is VABYSMO?

VABYSMO (faricimab-svoa) is a prescription medicine given by injection into the eye used to treat adults with neovascular (wet) age-related macular degeneration (AMD) and diabetic macular edema (DME).

Do not receive VABYSMO if you:

  • Have an infection in or around your eye. 
  • Have active swelling around your eye that may include pain and redness. 
  • Are allergic to VABYSMO or any of the ingredients in VABYSMO.

What is the most important information I should know about VABYSMO?

  • Injections like the one for VABYSMO can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment). Call your healthcare provider right away if you have increasing eye pain, vision loss, sensitivity to light, or redness in the white of the eye.
  • VABYSMO may cause a temporary increase in pressure in the eye (intraocular pressure), which occurs within 60 minutes after receiving the eye injection.
  • Although not common, VABYSMO patients have had serious, sometimes fatal, problems related to blood clots, such as heart attacks or strokes (thromboembolic events). In clinical studies for wet AMD during the first year, 7 out of 664 patients treated with VABYSMO reported such an event. In clinical studies for DME from baseline to week 100, 64 out of 1,262 patients treated with VABYSMO reported such an event.

Before receiving VABYSMO, tell your healthcare provider about all of your medical conditions, including if you:

  • Are pregnant or plan to become pregnant. Based on how VABYSMO interacts with your body, there may be a potential risk to your unborn baby. You should use birth control before your first injection, during your treatment with VABYSMO, and for 3 months after your last dose of VABYSMO.
  • Are breastfeeding or plan to breastfeed. It is not known if VABYSMO passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive VABYSMO.
  • Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about every medicine you take.

What should I avoid while receiving VABYSMO? 

  • Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects with VABYSMO?

  • The most common side effects with VABYSMO were cataract and blood on the white of the eye (conjunctival hemorrhage).
  • These are not all the possible side effects of VABYSMO.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to Genentech at 1-888-835-2555. 

Please see the VABYSMO full Prescribing Information for additional Important Safety Information.